It is very hygroscopic in the anhydrous form, and sparingly soluble in water (1:80). If you are a consumer or patient please visit

Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12. Tissue loading may occur at even lower rates of administration.

Gastrointestinal absorption of vitamin B12 depends on the presence of sufficient intrinsic factor and calcium ions. Each mL contains 1000 mcg Cyanocobalamin. Cyanocobalamin is indicated for vitamin B12 deficiencies due to malabsorption which may be associated with the following conditions: Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacteria overgrowth, total or partial gastrectomy. Intravenous administration results in even more rapid excretion with little opportunity for liver storage. The chemical name is Coα-[α(5,6-dimethylbenzimidazolyl)]-Coβ-cyanocobamide; the molecular formula is C63H88CoN14O14P. Cyanocobalamin is the most widely used form of vitamin B12, and has hematopoietic activity apparently identical to that of the antianemia factor in purified liver extract. The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. NDC 0143-9620-0110 mL Multiple Dose Vial Your doctor will order certain lab tests to check your body's response to cyanocobalamin injection. Medically reviewed by Drugs.com. Cyanocobalamin is quantitatively and rapidly absorbed from intramuscular and subcutaneous sites of injection; the plasma level of the compound reaches its peak within 1 hour after intramuscular injection.

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. However, vitamin B12 is an essential vitamin and requirements are increased during pregnancy.

Cyanocobalamin Injection, USP is also suitable for the vitamin B12 absorption test (Schilling test). It is used by mouth, by injection into a muscle, or as a nasal spray. Rx onlyCyanocobalaminInjection, USP30,000 mcg/30 mL(1,000 mcg/mL)For INTRAMUSCULAR orSUBCUTANEOULS USE ONLYContains Benzyl Alcoholas a Preservative However, vitamin B12 is an essential vitamin and requirements are increased during pregnancy. Like humans, dogs also receive injections of cyanocobalamin, with the dosage based upon body weight. HIKMA FARMACÊUTICA (PORTUGAL), S.A.Estrada do Rio da Mό, 8, 8A e 8B – Fervença – 2705-906 Terrugem SNT, PORTUGAL, Distributed by: What special precautions should I follow? Cyanocobalamin may also be used for purposes not listed in this medication guide.

If you become pregnant while using cyanocobalamin injection, call your doctor. Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration. As your red blood cells return to normal, you will probably receive the medication every other day for 2 weeks, and then every 3-4 days for 2-3 weeks.

Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Avoid using the intravenous route.

Each mL contains: Cyanocobalamin1,000 mcg, Sodium Chloride 9 mg,Benzyl Alcohol 0.015 mL in Water forInjection. Benzyl Alcohol has been reported to be associated with a fatal "Gasping Syndrome" in premature infants. 0143-9619-10, Keep all appointments to receive cyanocobalamin injections even if you feel well. What should I know about storage and disposal of this medication? The molecular weight is 1355.39. Cyanocobalamin injection also may be given as a test to see how well the body can absorb vitamin B12. Vitamin B12 is not present in foods of plant origin, but is abundant in foods of animal origin. It is less preferred than hydroxocobalamin for treating vitamin B12 deficiency. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Indiscriminate administration may mask the true diagnosis. FDA Safety Recalls, Gastrointestinal absorption of vitamin B12 depends on the presence of sufficient intrinsic factor and calcium ions. WARNING: PROTECT FROM LIGHT.Store at 20º to 25ºC (68º to 77ºF), If other vitamin deficiencies are present, they should be treated. © Copyright, 2020. https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=a66eb3c4-3e1d-4d49-b963-4fa2334cc9b6, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. pH 4.5-7.0 adjustedwith Hydrochloric Acid and/or SodiumHydroxide, if needed. The injections may be given subcutaneously -- beneath the skin -- or intramuscularly, typically in the thigh of the hind leg. What side effects can this medication cause? Patients with Normal Intestinal Absorption, We comply with the HONcode standard for trustworthy health information -, ANALYSIS(68083-449), MANUFACTURE(68083-449), PACK(68083-449), Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacteria overgrowth, total or partial gastrectomy. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Amounts of vitamin B12 that are recommended by the Food and Nutrition Board, National Academy of Science-National Research Council for lactating women (4 mcg daily) should be consumed during lactation. A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any vitamin B12.

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